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Loss of firmness

Intrathecal administration, while conceptually the most direct way to approach brain iron, is highly invasive and currently studied only in experimental scenariosit may be considered in extreme cases or acute CNS iron toxicosis, but it is not a routine approach due to the safety and logistical challenges

In these studies, graded exercise tests and time-to-exhaustion tests assessed exercise tolerance, while time trials measured endurance exercise performance (Van De Walle and Vukovich, 2018)

Bone 38 , 119124 (2006)

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