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Ultimately, whether p53 induces cell cycle arrest, apoptosis, or senescence depends on the type of cell and the nature of the DNA damage

If your total energy intake is low, your body prioritises using that energy for brain and vital organ functions, like your heart pumping blood around your body and your kidneys filtering waste and forming urine, as opposed to maintaining or building muscle

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This method also activates the mitochondrial system, initiating an apoptosis signaling amplification loop through cleavage of the BH3-interacting-domain death agonist (BID) protein, producing the active truncated BID fragment and ensuring irreversible cell death (73)