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The decrease in HbA 1c of 0.88%-points (9.64 mmol/mol) in this study compares to a mean 0.9%-point decrease reported in the IGNITE study, an observational study ( n = 211) evaluating oral semaglutide use in routine clinical practice in participants with T2D in the USA [25], and to a mean 1.3% reduction in the Swedish cohort ( n = 195) of the SURE study, an observational study of subcutaneously administered semaglutide use in routine clinical practice [26]

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Regular physical activity throughout the week aiming for at least 150 minutes of moderate-intensity exercise as recommended by NHS guidelines supports overall gastrointestinal function

Its clinical trial safety profile was described as indistinguishable from placebo