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10.1016/j.cell.2008.06.028 29 CaiW

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This mutation results in protein accumulation within the endoplasmic reticulum (ER) of hepatocytes and other AAT-producing cells, which leads to ER stress or an aberrant inflammatory response

Compared to the liver, we observed that the kidney has: (1) similar increased use of energy-related metabolites and production of urea cycle and ammonia-related intermediates, suggesting a shared catabolism in AKI, and (2) higher pools of energy metabolism intermediates in AKI