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The most frequently reported adverse effects include: Nausea and vomiting affecting 20-44% of patients (varies by product), particularly during dose escalation Diarrhoea experienced by approximately 18-30% of users depending on the specific medication Constipation occurring in around 19-24% of patients Abdominal pain or discomfort reported by 15-25% of individuals Reduced appetite whilst therapeutically desired, this can sometimes be excessive Dyspepsia and acid reflux affecting a smaller proportion of users These gastrointestinal effects typically emerge during the initial weeks of treatment or following dose increases