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Compared with the whole worm (Nakamura et al, 2016), DTC shows common and characteristic gene expression upon the loss of germline

105 , 125 , 126 , 127 This polarization is at least partly mediated via cAMP/PKA signalling, a canonical downstream pathway of GLP1R activation that has been implicated in suppressing NFB activity and dampening proinflammatory transcriptional programs

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These reactions usually resolve within a few days and rarely require treatment discontinuation

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