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1 The majority of these patients are diagnosed with type 2 diabetes, which is characterized by insulin resistance and diminished beta-cell function

For example, INT-777 and MN6, TGR5 selective agonists, stimulated GLP-1 secretion and improved insulin sensitivity in diet-induced obesity (DIO) mice [180, 181]

When ROS levels exceed the antioxidant defenses, spermatozoa are subjected to oxidative stress, leading to detrimental molecular changes, including lipid peroxidation, DNA fragmentation, and protein oxidation

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