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Epac2 interaction with Rim2 and Piccolo is crucial for cAMP-induced Ca 2+ -dependent insulin secretion and is not blocked by inhibition of PKA [493,512,513]

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Notably, cells treated with CaOX showed a reduced PI-positive ratio in the Acsl4 knockout ( Acsl4 / ) group compared to the Acsl4 wild-type ( Acsl4 +/+ ) group (Fig

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