Unfortunately, these hydrophobic ligands are not soluble in water and hence require the addition of miscible organic co-solvents, which disrupts significantly the colloidal stability of GSH-AuNCs and results in severe and irreversible precipitation (unsuccessful attempts in this direction are discussed in Fig
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Encapsulation of DDA-GSH-AuNCs into PLGA nanoparticles using the emulsion-evaporation method PLGA (30 mg) was dissolved in chloroform containing DDA-GSH-AuNCs (1.5 mL), and then emulsified into aqueous PVA solution (2.5% w/w, 5.0 mL) using sonication for 60 s (ultra-probe sonicator at 50 W, UP200Ht, Hielscher Ultrasonics, Teltow, Germany)
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