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In this respect, CaP treatments could influence the composition of the ligand milieu, which may further impact on AR conformations and action as ligand represents the third determinant of NR allostery [77]

Furthermore, t-distributed Stochastic Neighbor Embedding (t-SNE) clustering under disease conditions ( Figure 6B ) reveals pathological remodeling of renal cellular subpopulations in acute kidney disease (AKD) and CKD, establishing a foundation for exploring the cell-selective roles of ferroptosis during renal injury progression

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