nature semaglutide New in Communications: in a randomized placebo-controlled trial, slowed several biological aging clocks by the equivalent of 2 to 5 years. UC San Diego published a secondary analysis of a SkinnyRx | Compounded Injectable Semaglutide

Weight loss edge: tirzepatide The clinical evidence is now definitive tirzepatide produces greater average weight loss than semaglutide across trials and real-world data

Evidence-based obesity treatments include lifestyle modification, licensed medications (orlistat, semaglutide, liraglutide), and bariatric surgery for appropriate patients

The letter lands as GLP-1 litigation accelerates: MDL-3094 now carries 3,363 pending cases a 153% increase since January 2025 with expert discovery due March 27 and first bellwether trials expected mid-2026

Freezing creates ice crystals that physically puncture peptide molecules, causing irreversible damage

There are no exceptions