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Future perspectives and outstanding questions Despite substantial progress, several unmet needs and key questions require investigation to fully realize the therapeutic potential of GLP-1-based therapies in MASLD/MASH

Kohrt advises women in midlife who want to use GLP-1 drugs to lose weight to also think carefully about how weight loss will affect their bone health

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However, the gene expression data provide a whole genome view, and integration of the two data sets provides additional confidence in the associations observed