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However, many prescribers continue phentermine beyond 12 weeks off-label for patients who respond well, do not develop side effects, and have no cardiovascular contraindications

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The longer-duration ADT patients also had more than double the Alzheimers risk of non-ADT controls

While this association was exploratory, the directionality is biologically plausible and consistent with prior studies linking accelerated epigenetic aging to frailty, slower gait speed, and functional decline in older adults 27,28

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