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M1 macrophages are induced by inflammatory mediators such as bacterial lipopolysaccharides and are characterized by the production of proinflammatory cytokines such as IFN-, IL-1, IL-12, iNOS, TNF-, and reactive oxygen species

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Research by Yousefi et al (106) using a topical extract of N

Among prediabetic participants, 87.7% reverted to normoglycemia with the combination, compared with 32.2% on placebo

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