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The main protease (M pro ), or 3C-like protease (3CL pro ), is an extremely important protease in the propagation of other coronaviruses, such as Middle East Respiratory Syndrome Coronavirus (MERS-CoV), which is responsible for the cleavage of protein precursors of the translated viral genome, resulting in a number of nonstructural proteins (NSPs), that assemble to form the viral replication-transcription enzyme complex NSPs

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Petyaev IM, Dovgalevsky PY, Chalyk NE, Klochkov VA, Kyle NH, Bashmakov YK

Additionally, interindividual variability in pharmacologic response, baseline eating patterns, and metabolic factors influence treatment response

In people with type 1 diabetes, the pancreas does not produce insulin