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20 Several reports have demonstrated the antinociceptive-like effects of morphine and related compounds on formalin-induced behaviors

This unusual stability allows for more flexible administration routes and potentially less frequent dosing when oral delivery is employed, as peak plasma concentrations are reached more slowly and clearance follows a more gradual curve compared to subcutaneous injection

It minimises material investment in the early stages of a research project

Washout periods: for crossover designs, a 7-14 day washout should be adequate given both short serum half-life and the typical decay timeline of tissue-level effects post-dosing

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