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While earlier GLP-1 drugs have decades of data behind them, newer high-potency agonists and multi-agonist combinations will require extended monitoring as their use expands

Lipid improvements typically become statistically significant by 12-26 weeks

This represents a fundamentally different approach from simply eating less, which can further suppress metabolism in an already downregulated system

The initial response might reflect the inhibitory effect of activation of GLP-1 receptors, as suggested by Oshima et al