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However, despite these beneficial effects, the persistence of the high-fat diet in the experimental model appears to have limited the ability of semaglutide to completely reverse the pathological activation of microglia

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International Journal of Pharmaceutics , 249(1-2), 101108.) Polymeric nanoparticles are with pharmaceutical advantages: 1) Comparing to other colloidal carriers like liposomes, they are more stable in the GI tract and can prevent encapsulated drugs damaging from the GI environment