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Fluorescent GLP1R/GIPR dual agonist probes reveal cell targets in the pancreas and brain

While we have added more information where possible, much of the current research regarding receptor dimerization have been conducted on cell lines

We showed that mice fed a high-fat diet (HFD) for 12 weeks developed hepatic steatosis and liver injuries, which were associated with not only TNF overproduction but also hepatic glutathione dysregulation, characterized by GSH reduction and GSSG elevation

In fact, molecules that are activated as NHS esters can be dried and stored for later reaction to amine-containing targets