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CJC-1295, with its longer half-life, allows for fewer injections and a steadier release pattern
doi: 10.1016/S2213-8587(23)00171-7 69 GiuglianoDLongoMSignorielloSMaiorinoMISolerteBChiodiniPet al
Treatment stage What may be common What deserves attention Week 1 Nausea, fullness, reduced appetite, bloating, indigestion, diarrhea, constipation, fatigue Repeated vomiting, severe pain, inability to stay hydrated Weeks 2 to 4 Early symptoms may settle, persist, or fluctuate Symptoms interfering with eating, drinking, or daily function Weeks 5 to 8 Symptoms may reappear after clinician-directed dose escalation A significant return or worsening of gastrointestinal symptoms Months 2 to 3 Some patients tolerate treatment more comfortably
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