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Gastrointestinal Adverse Reactions In clinical trials in adults for weight reduction, 73% of WEGOVY-treated patients and 47% of patients receiving placebo reported gastrointestinal adverse reactions, including severe reactions that were reported more frequently among patients receiving WEGOVY (4.1%) than placebo (0.9%)

However, phase 2 results frequently attenuate in larger trials

Minakova et al., Melanotan-II reverses autistic features in a maternal immune activation mouse model, PLoS ONE, 2019

GLP-1 medications are not substitutes for established psoriasis therapies

It is the reverse of the water weight you gained when starting