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This suggests that circulating GLP-1 levels largely determine how much of the hormone reaches the joint space
However, because they initially absorb through oral membranes, bypassing the stomach to go straight to the bloodstream, they shouldnt need as high of a dose.6 Research indicates a certain amount of difficulty absorbing peptides through regular digestion, so sublingual absorption could prove superior.7 The only problem is that sublingual delivery mechanisms for semaglutide haven't been tested to establish an effective dose outside of the compounding pharmacy industrys internal publications, which are more marketing materials than clinical research
The study reviewed 79 websites offering compounded GLP-1 receptor agonists like semaglutide and tirzepatide and found notable transparency issues: Compounded drugs are often produced during shortages of brand-name medications but lack FDA oversight for safety and efficacy
Individualized Approach Not everyone needs to stay on GLP-1 agonists indefinitely
doi: 10.1016/j.eclinm.2024.102789
