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Improved energy levels: By increasing dopamine and norepinephrine levels, bupropion increases energy and motivation, which may stimulate patients to be more physically acti Increased metabolism: Some evidence indicates that bupropion may be able to increase metabolism by a small amount, although the data around this is unclear

et al.) (MDText.com, 2000)

Novartis has filed no meaningful conversion or product-hopping strategy for Entresto, making it a clean cliff rather than a managed LOE event

Both mechanisms increase cytoplasmic concentrations of dopamine (DA), norepinephrine (NE), and serotonin (5-HT), producing a cytoplasmic surge of monoamines