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The ability to normalize glucose metabolism before type 2 diabetes develops may alter health trajectories in ways that extend far beyond weight loss

This can lead to leaky gut, a condition that worsens digestion and nutrient absorption, including B12

While melatonin has a direct effect on oxidative stress by scavenging ROS and RNS (1), its metabolites (product of its degradation) are also active and act indirectly by inducing the production of anti-oxidative enzymes and lowering the synthesis of pro-oxidative molecules (2) leading to an overall reduction of oxidative stress

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16 , 16221631.e1623 (2018)