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Understanding GLP1 and GIP Medications Before we compare semaglutide and tirzepatide, it helps to get a clear picture of what these medications actually do

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While GLP-1 drugs have not been extensively tested onindividuals with obesity, they have the side effect of sending fullness signals to the brain, which produces an anti-appetiteeffect leading to weight loss

However, it is the topographical distribution of these receptors across functionally distinct brain regionsparticularly those implicated in motivation, reinforcement, and rewardthat has garnered increasing attention in the context of addiction neurobiology

PMID: 12010235