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Preclinical evidence supports the role of GLP-1RAs in alleviating neuropathic pain through the modulation of microglial activity, inflammatory cytokine production and -endorphin release [63, 65, 68, 70,71,72,73,74]

doi: 10.3389/fimmu.2026.1823915 Received 05 March 2026 Revised 07 April 2026 Accepted 20 April 2026 Published 29 April 2026 Volume 17 - 2026 Edited by Hao Wang, Zhengzhou University, China Reviewed by Yi Zhang, Shanghai Jiao Tong University, China Sudhir Varma, Ajman University, United Arab Emirates Updates Copyright 2026 Li, Sun, Xie, Li, Guo and Lan

Assessment of the insulin response to a mixed meal by mathematical model analysis indicated that vildagliptin would improve -cell function in the short (28 days) and long term (52 weeks) [44,45]

This approach can support post-market safety and effectiveness studies, enable synthetic control arms for clinical research, and provide a more complete and timely view of patient journeys

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