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It occurs naturally in human plasma, saliva, and urine, and its plasma concentration declines significantly with age, from approximately 200 ng/mL in young adults to much lower levels in older individuals

However, it is not part of our current treatment offerings

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Staying hydrated and reducing caffeine, which dehydrates the skin, also helps

Future research should focus on vector development for enhanced specificity and safety and optimize CRISPR-based approaches for long-term gene editing in DN-related genes