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Collectively, these dynamics position oral GLP-1s as a catalyst for large-scale adoption, supporting access, acceptance and operational scalability in ways injectables cannot fully achieve

Four amino-acid substitutions make the core peptide resistant to dipeptidyl peptidase IV (DPP-IV) cleavage, and a drug affinity complex (DAC) linker lets the molecule covalently bind endogenous albumin after injection, extending its half-life to a duration similar to albumin's

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