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Subcutaneous (SubQ) injection of GHK-Cu outperforms intramuscular (IM) for cosmetic applications because adipose tissue acts as a sustained-release depot, extending plasma half-life by 4060% while maintaining therapeutic copper-peptide concentrations at the dermal layer

Its safety profile is well-established, with the most common side effects being mild gastrointestinal issues such as nausea, vomiting, and diarrhea

Studies confirm that GLP-1 medications do not increase intestinal permeability, reduce nutrient absorption in healing villi, or trigger celiac-related inflammation

JACC Basic Transl Sci 3(4):503517

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