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While this can be normal for some people on Semaglutide, its important to keep an eye on any lasting changes

Metabolic improvements: beyond weight and blood sugar, studies showed decreases in fasting glucose, reductions in waist circumference (a proxy for visceral fat), and favorable shifts in lipid markers in many participants

Wessner B, Strasser EM, Koitz N, Schmuckenschlager C, Unger-Manhart N, Roth E

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But pain that becomes severe, lasts for weeks, spreads into the shoulder or arm, limits movement, or interferes with sleep and daily activities may indicate something beyond a routine vaccine reaction