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These patients need aggressive treatment with more than one medication

As of August 2025, more than 2,190 cases are consolidated in a federal multidistrict litigation (MDL 3094) in the Eastern District of Pennsylvania, overseen by Judge Gene E.K

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284 In a phase 3 clinical trial, 284 eplontersen significantly reduced circulating TTR levels, mitigated nerve damage, and improved quality of life in ATTR-PN patients, resulting in its FDA approval in December 2023 for treating ATTR-PN

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