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44 Interestingly, other macronutrients (for example fatty acids) do not induce proinsulin biosynthesis, in spite of their ability to act as potent secretagogues for insulin secretion

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"Constipation from GLP-1s can be compounded by the fact that people are eating less," says Hamilton, "resulting often in less fiber consumption and less stool bulk overall." Many people also drink less fluid to avoid feeling overly full on GLP-1 medications, which can also lead to constipation