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Kim, Jiyoong, et al

In the context of early brain injury following subarachnoid hemorrhage (SAH), topiramate significantly reduced the elevated levels of TNF-, IL-1, and IL-6 induced by SAH, suggesting that topiramate may exert neuroprotection via its anti-inflammatory effects (Tian et al., 2015)

C-reactive protein (CRP), an active regulator of host innate immunity, is a biomarker of severe COVID-19 disease, including lung and atherosclerotic disease progression

Additional mechanistic studies demonstrated that both dihexa and Nle 1 -AngIV, its parent compound, were effective stimulators of hippocampal synaptogenesis, thus providing a rational explanation for their procognitive activities

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