Here is what each group received: 1mg group: 1mg weekly for the full 48 weeks, no escalation 4mg (starting at 2mg): Started at 2mg, escalated to 4mg after 4 weeks 4mg (starting at 4mg): Started directly at 4mg, no escalation 8mg (starting at 2mg): Started at 2mg, escalated through 4mg to reach 8mg 8mg (starting at 4mg): Started at 4mg, escalated to 8mg after 4 weeks 12mg (starting at 2mg): Started at 2mg, escalated through 4mg, 8mg to reach 12mg The weight loss results at 48 weeks told a clear story
The tissue it is supposed to calm simply does not have enough receptors to hear the signal
Why these stacks are popular right now A few converging reasons
Patients experiencing a plateau should have thyroid function tests (TSH, free T4) checked if not recently assessed, as thyroid disorders affect approximately 2% of the UK population (NICE NG145) and often develop insidiously
The first month of Wegovy usage is usually based on helping the body get used to the medicines effects and hence prominent weight loss is not observed however an overall weight loss of 2-4% is common during this time
