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While some lean mass loss inevitably occurs during significant weight reduction, the rate is typically 20-25% of total weight lost on tirzepatide compared to 30-40% with diet-only approaches

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A 20 percent LDL reduction from a weight-loss-oriented triple agonist is therefore a genuinely new observation and helps explain why retatrutide is being developed across cardiovascular, metabolic, and weight-related indications rather than as a pure obesity asset