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Mutations in the mitochondrial Fe-S cluster biosynthesis or relay machineries have been shown to dramatically blunt respiration in multiple model systems, most notably affecting complex I and II stability
The most common side effects that were seen in people with pancreatic cancer treated with ONIVYDE include: diarrhea, feeling tired, vomiting, nausea, decreased appetite, inflammation in the mouth, fever, and dehydration
By ensuring that the overall bodily pool of cobalamin is replete, the body can efficiently convert necessary amounts into adenosylcobalamin to fuel the mitochondria
doi: 10.1186/s12986-019-0410-3 55 XuYHuangXHuangfuBHuYXuJGaoRet al
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