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In perfect study situations where all medications are covered and patients receive great counseling support and follow-up, the quit rates are reported to be upwards of ~35-40%
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8.1.4 Research limitations and considerations While the evidence is compelling, several limitations must be acknowledged, including the reliance on observational studies for human data, potential confounding factors in epidemiological investigations, and the extrapolation challenges from animal models to human populations
doi: 10.1089/jop.2011.0049
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