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Rational engineering of Escherichia coli Nissle 1917 as live biotherapeutic to degrade uremic toxin precursors

Borderline levels of low total testosterone (15.1mmol/l) [435.1 ng/dL] also increased the risk of an early death

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Together, our results provide a detailed structural and mechanistic framework of CCR8 activation and inhibition that expands our molecular understanding of chemokine - receptor interactions and offers insight into the development of therapeutic antibodies targeting chemokine GPCRs

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