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Patients should be educated about potential symptoms of thyroid tumors, including persistent hoarseness, difficulty swallowing, or a neck mass, though these symptoms are rare and may have many other causes

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These comparative results align with the arm-level results for respective trials, with liraglutide having the smallest change from baseline (range 6.6% to 9.2%), followed by tirzepatide 5 mg ( 16.0%), semaglutide (range 16.6% to 17.1%), tirzepatide 10 mg ( 21.4%) and tirzepatide 15 mg ( 22.5%) (Supplementary Material Table S9)

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doi: 10.4049/jimmunol.167.8.4137 128 LiTJJiangYMHuYFHuangLYuJZhaoLYet al

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Early human trials provide signals of target engagement, such as preserved cerebral glucose metabolism, altered inflammatory biomarkers, and slowed brain atrophy, although clinical outcomes to date remain mixed and trials in rarer disorders are sparse

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