You know, you see it in all sorts of different disciplines
Studies looking at NR doses up to 2,000mg per day and NMN doses up to 1,200mg per day found no differences in adverse effects between intervention and placebo groups.31 4 In studies of higher doses that produced adverse effects, typical reactions included:32 Headache Dry mouth GI upset Muscle cramps or spasms As with many forms of vitamin B, NR can cause some flushing, and both NR and NMN can cause digestive upset
In many scenarios, activation of NRF2 has been reported to be a stress response that is required to prevent the accumulation of oxidative stress and subsequent tissue damage
Avoid freezing reconstituted solutions, as this may degrade peptide integrity
Proteomics 18:e1800008 Park E, Chung SW (2019) ROS-mediated autophagy increases intracellular iron levels and ferroptosis by ferritin and transferrin receptor regulation