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Consistent with observations in aged pancreatic islet cells, MOTS-c treatment in H 2 O 2 -induced senescent Min6 cells appeared to further reduce glutamate and malate levels (Supplementary Fig

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GIP, and perhaps to a lesser extent GLP-1, which does not present clear evidence of bone metabolism, act on bone remodeling through the effects on osteoclasts and osteoblasts [43]

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