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This impaired clearance would also be compounded by exogenous copper downregulating LRP1 expression (Singh et al., 2013), that could further impede CNS clearance of LRP1 ligands such as Tau or A

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Our analysis demonstrates that thiamine insufficiency restricted to the gastrointestinal system, i.e., lacking well-known symptoms of dry and wet beriberi, may arise through (i) a disbalance between the nutrient influx and efflux in the gastrointestinal system due to increased demands of thiamine by the organism