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The results in Phase 2 and MASLD substudy data: 86% liver fat reduction in the MASLD-selected substudy with 93% of patients on the highest dose achieving complete clearance on MRI (below 5% liver fat content by imaging a different endpoint from the histologic MASH resolution measured in ESSENCE and SYNERGY-NASH) 35-45% triglyceride reduction roughly double what semaglutide achieves Meaningful LDL reduction (~20% at the highest dose) larger than semaglutide or tirzepatide, but still not statin-like

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Risks, Benefits, and Treatment Modalities of Menopausal Hormone Therapy: Current Concepts