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In our study, we did not observe an increase in loose stools in NAC-treated animals during daily monitoring, consistent with previous research showing no toxicity after 30 days of high-dose NAC (1200 mg/kg/day) in rats [109]

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To investigate the molecular basis of this specificity, we examined the alpha-fold generated models of Histone fold (HF) domains of two CaTaf12 variants (Taf12 and Taf12L), Taf4 and Ada1 as well as alpha-fold model of heterodimers of Histone fold (HF) domains of Taf12-Taf4, Taf12L-Taf4, Taf12-Ada1 and Taf12L-Ada1