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A structured assessment of possible nonindependence across observational reports is provided in Appendix S2

When you combine that with the appetite suppression from GLP-1 and GIP, you get a drug that hits weight loss from two directions at once

Similarly, a post hoc analysis of changes in weight, waist circumference and HbA 1c for this subset of participants is shown in Supplementary Table 1

Therefore, there appear to be as yet unknown pathways by which metformin can acutely increase GLP-1 secretion

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