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VPA has also been found to remarkably raise lamotrigine levels in plasma (to double its half-life), presumably causing the severe and a potentially fatal rash, such as toxic epidermal necrolysis and Stevens-Johnson syndrome, as well as disabling ataxia and tremors, which are known as lamotrigine's secondary effects (Arif et al., 2007)

These effects can be partially reversed by restoring GSH levels, suggesting that GSH may contribute to cell death-associated responses in a context-dependent manner 212

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