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Notably, Smad3 , which acts primarily downstream of the TGF-activin pathway and is predicted to drive early gene expression changes in HD 23 , was significantly upregulated in the iSPN + mut subpopulation at 8 months (Extended Data Fig

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Parkinsons disease (PD) is one of the most common neurological disorders caused by the death of dopamine-secreting neurons in the brain due to aggregation of synuclein protein inside it

Whilst most patients experience mild to moderate nausea or delayed digestion, some may develop more pronounced symptoms consistent with gastroparesis

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