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The limit of quantification was 2.5 ng/dL and the intra-assay coefficient of variation (CV) was 9.1% at concentration 14 ng/dL, and inter-assay CV was 9.3% at a concentration 26 ng/dL

If deficiency or tissue utilization concerns arise, functional markers like methylmalonic acid (MMA) and homocysteine levels may offer additional context (source: Harvard T.H

The combination of unverified formulation, uncertain sterility, and unknown systemic effects creates a perioperative exposure that cannot be reliably risk-stratified

Studies highlight its anti-inflammatory effects against inflammation, thyrocyte damage, and apoptosis

[42] The American College of Obstetricians and Gynecologists states that while they can be used in the first trimester other options may be preferred