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In STEP-1 (semaglutide), lean mass decreased by ~9.7% while fat mass fell by ~19.3%, with the proportion of lean mass increasing by ~3 percentage points ( Limited preclinical and clinical data, particularly from MRI-based studies, suggest that skeletal muscle changes induced by GLP-1RAs may be adaptive

On the other hand, the configuration of those proteins absorbed on the NP surface would be altered, which leads to a change in their functional activity and biological processes (Tomak et al., 2021)

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doi: 10.1097/00041327-200306000-00012 [DOI] [PubMed] [Google Scholar] 40.Toosy AT, Mason DF, Miller DH

Nature medicine 2016;22, 78-83, doi:10.1038/nm.4010