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Effects of 17-estradiol and antioxidant administration on oxidative stress and insulin resistance in ovariectomized rats

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For instance, 520-nm Poly(lactic-co-glycolic acid) nanoparticles can be detected in neuronal bundles after intranasal administration, indicating their transcellular neuronal transport, whereas 80-nm and 175-nm particles were only detected in other cell types, albeit with a more rapid distribution [49]

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Loss of redox flexibility compromises protein thiol regulation, redox-sensitive signaling pathways, and endothelial homeostasis, positioning glutathione insufficiency as a primary upstream disturbance rather than a downstream consequence of disease (1-3)